PCP Signaling and Ciliogenesis in Vertebrate Embryos
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چکیده
منابع مشابه
The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium
The planar cell polarity (PCP) pathway controls multiple cellular processes during vertebrate development. Recently the PCP pathway was implicated in ciliogenesis and in ciliary function. The primary cilium is an apically projecting solitary organelle that is generated via polarized intracellular trafficking. Because it acts as a signaling nexus, defects in ciliogenesis or cilial function cause...
متن کاملS03-02. From cell mechanics to tissue morphogenesis
The planar cell polarity (PCP) signaling pathway is essential for a wide variety of celland tissue-level morphogenetic events in developing embryos. PCP research has been predominantly directed at the role played by a small number of core proteins, including Dishevelled and Frizzled. Much less is known about how these proteins signal downstream to direct the execution of such diverse cell behav...
متن کاملS03-03. High resolution live microscopy of cell motility, actin dynamics and cell-cell contacts along embryonic tissue boundaries
The planar cell polarity (PCP) signaling pathway is essential for a wide variety of celland tissue-level morphogenetic events in developing embryos. PCP research has been predominantly directed at the role played by a small number of core proteins, including Dishevelled and Frizzled. Much less is known about how these proteins signal downstream to direct the execution of such diverse cell behav...
متن کاملS03-01. Planar cell polarity: Linking developmental regulatory mechanisms to basic cellular machinery during morphogenesis
The planar cell polarity (PCP) signaling pathway is essential for a wide variety of celland tissue-level morphogenetic events in developing embryos. PCP research has been predominantly directed at the role played by a small number of core proteins, including Dishevelled and Frizzled. Much less is known about how these proteins signal downstream to direct the execution of such diverse cell behav...
متن کاملPrickle3 synergizes with Wtip to regulate basal body organization and cilia growth.
PCP proteins maintain planar polarity in many epithelial tissues and have been implicated in cilia development in vertebrate embryos. In this study we examine Prickle3 (Pk3), a vertebrate homologue of Drosophila Prickle, in Xenopus gastrocoel roof plate (GRP). GRP is a tissue equivalent to the mouse node, in which cilia-generated flow promotes left-right patterning. We show that Pk3 is enriched...
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تاریخ انتشار 2008